Oct 2021
Primary Cutaneous B-cell Lymphomas
Reviewer(s): Dharam Ramnani, MD
Primary cutaneous B-cell lymphomas (PCBCLs) are a heterogenous group of mostly low-grade B-cell lymphomas (exceptions exist) that involve skin with no evidence of extracutaneous disease at presentation. They are less common than cutaneous T-cell lymphomas and make up 20-25% of all primary cutaneous lymphomas.
The 2018 WHO-EORTC update of classification of primary cutaneous lymphomas includes the following PCBCLs:
References:
1. Jaffe, ES et al (2017). Hematopathology - Second Ed. Philadelphia, PA. Elsevier.
2. Swerdlow, SH et al (2017). WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues, Revised 4th Ed.; IARC, Lyon, France.
3. Calonje, E et al (2020). McKee's Pathology of the Skin with Clinical Correlations - 5th Ed. Elsevier.
4. Skala SL, Hristov B, Hristov AC. Primary Cutaneous Follicle Center Lymphoma. Arch Pathol Lab Med. 2018;142:1313-1321.
5. Dumont M et al. Diagnosis and Treatment of Primary Cutaneous B-Cell Lymphomas: State of the Art and Perspectives. Cancers 2020, 12, 1497.
The 2018 WHO-EORTC update of classification of primary cutaneous lymphomas includes the following PCBCLs:
- cutaneous follicle center lymphoma
- cutaneous marginal zone lymphoma
- cutaneous diffuse large B-cell lymphoma - leg type
References:
1. Jaffe, ES et al (2017). Hematopathology - Second Ed. Philadelphia, PA. Elsevier.
2. Swerdlow, SH et al (2017). WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues, Revised 4th Ed.; IARC, Lyon, France.
3. Calonje, E et al (2020). McKee's Pathology of the Skin with Clinical Correlations - 5th Ed. Elsevier.
4. Skala SL, Hristov B, Hristov AC. Primary Cutaneous Follicle Center Lymphoma. Arch Pathol Lab Med. 2018;142:1313-1321.
5. Dumont M et al. Diagnosis and Treatment of Primary Cutaneous B-Cell Lymphomas: State of the Art and Perspectives. Cancers 2020, 12, 1497.