Cutaneous Follicle Center Lymphoma : Morphology

Comments:
Morphology: The neoplastic lymphocytes in primary cutaneous follicle center lymphoma show diffuse growth pattern (most common; 64% of cases) or follicular and diffuse or predominantly follicular pattern (least common; shown here).

The neoplastic follicles have the following features:

• closely spaced together
• irregular, ill-defined borders
• poorly-formed or absent mantle zones
• monotonous appearance; no differentiation into polarized light and dark zones
• few or no tingible body macrophages
• lower proliferation rate than reactive germinal centers