Myeloma Kidney : Amyloid

Comments:
In up to 25% of myeloma patients, the renal damage is mediated by the development of amyloidosis of AL type due to deposition of free light chains (lambda type) in the interstitium. In some patients, there is deposition of kappa light chains in the glomerular basement membranes, mesangial matrix, as well as in the tubular basement membrane. This low power view shows plasma cells scattered about in the renal interstitium which contains abundant amyloid deposits.