Myeloma Kidney : Amyloid

Comments:
In up to 25% of myeloma patients, the renal damage is mediated by the development of amyloidosis of AL type due to deposition of free light chains (lambda type) in the interstitium. In some patients, there is deposition of kappa light chains in the glomerular basement membranes, mesangial matrix, as well as in the tubular basement membrane. Higher magnification of the previous image showing neoplastic plasma cells and amyloid deposits in the renal interstitium in a myeloma kidney.