 |
|
|
1:
Prostatic Adenocarcinoma - Atrophic Variant
|
|
Comments: At low magnification, the majority of the glands in this needle biopsy have open dilated lumens and appear to be lined by flattened “atrophic” epithelium. However, this is an example of atrophic pattern of prostatic adenocarcinoma.
|
|
|
|
|
|
2:
Prostatic Adenocarcinoma - Atrophic Variant
|
|
Comments: The presence of prominent nucleoli and the absence of basal cell layer are features distinguishing it from benign atrophic glands. In the majority of cases, the presence of usual pattern (non-atrophic) of adenocarcinoma nearby is the main clue to correct diagnosis.
|
|
|
|
|
|
3:
Prostatic Adenocarcinoma - Foamy Gland Variant
|
|
Comments: This variant of prostatic adenocarcinoma shows abundant foamy cytoplasm in the tumor cells. Nuclear and nucleolar enlargement may be minimal; this case, however, shows enlarged nuclei with prominent nucleoli.
|
|
|
|
|
|
4:
Prostatic Adenocarcinoma - Neuroendocrine Cells
|
|
Comments: The spectrum of neuroendocrine differentiation in prostate cancer ranges from neuroendocrine cells with large eosinophilic granules (as seen in this case) to carcinoid-like pattern to small cell carcinoma.
|
|
|
|
|
|
|
|
|
|
7:
Prostate - Small Cell Carcinoma
|
|
Comments: Note the usual features of small cell carcinoma including, nuclear hyperchromasia, nuclear molding, small punctate nucleoli, and brisk mitotic activity.
|
|
|
|
|
|
|
|
9:
Prostatic Adenocarcinoma - Mucin Producing
|
|
Comments: Mucin-producing prostatic adenocarcinoma in a needle biopsy. Many glands are “floating” in pools of mucin. It is considered equivalent to Gleason grade 4.
|
|
|
|
|
|
10:
Prostatic Adenocarcinoma - Mucin Producing
|
|
Comments: A focus of mucin-producing adenocarcinoma from a radical prostatectomy specimen. Note the glandular fusion (Gleason grade 4). The bulk of the tumor was usual acinar adenocarcinoma, Gleason grade 3.
|
|
|
|
|
|
11:
Prostatic Adenocarcinoma - Signet Ring Cell Pattern
|
|
Comments: At least 25% or more of the tumor should consist of this pattern to apply the designation signet ring cell carcinoma. More often seen as a minor component of Gleason grade 5 adenocarcinoma.
|
|
|
|
|
|
|
|
13:
Prostatic Adenocarcinoma - Ductal Type
|
|
Comments: The tumor consists of tall columnar cells arranged in papillary and ductal configurations. The majority of the cases contain foci of usual acinar adenocarcinoma. Controversy exists as to whether or not the ductal adenocarcinoma of prostate has worse prognosis than usual acinar adenocarcinoma.
|
|
|
|
|
|
14:
Prostatic Adenocarcinoma - Ductal Type
|
|
Comments: The differential diagnosis of ductal adenocarcinoma of prostate includes urothelial carcinoma involving prostate, metastatic adenocarcinoma, and high-grade PIN among others. Arrow points to a mitotic figure in this image.
|
|
|
|
|
|
15:
Prostate - Adenoid Basal Cell Tumor
|
|
Comments: It is considered to be a low-grade tumor but with potential of malignant behavior with distant metastases. Note the solid clusters of basaloid cells, some with punched-out lumens.
|
|
|
|
|
|
16:
Prostate - Adenoid Basal Cell Tumor
|
|
Comments: Note the bland cytology and resemblance to basal cell hyperplasia; however, the lesion involved a large area of TUR specimen and was not circumscribed.
|
|
|
|
|
|
17:
Prostate - Adenoid Basal Cell Tumor - Keratin
|
|
Comments: Immunostain for high molecular weight keratin 34bE12 shows stronger staining in the center of the clusters than at periphery. The cells usually lack immunoreactivity for PSA and PAP.
|
|
|
|
|
|
18:
Prostate - Urothelial Carcinoma
|
|
Comments: Usually it represents a spread from carcinoma in the bladder or urethra. In this case, the tumor is localized to the larger prostatic ducts and did not show definitive evidence of stromal invasion. Distinction from Gleason grade 5 adenocarcinoma is important.
|
|
|
