Gleason Score 5+5; PSA Immunostain

Comments:
Solid sheet of relatively uniform neoplastic cells diagnostic of Gleason score 5+5=10. In such cases, one has to consider and rule out high-grade urothelial carcinoma or metastases from other sites. Urothelial carcinoma typically shows greater degree of pleomorphism and mitotic activity. Immunostaining with prostatic markers can help in challenging cases. The tumor was strongly immunoreactive for prostatic markers PSA (shown here) and PAP confirming prostatic origin.