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Gleason Score 5+5

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Solid sheet of relatively uniform neoplastic cells diagnostic of Gleason score 5+5=10. In such cases, one has to consider and rule out high-grade urothelial carcinoma or metastases from other sites. Urothelial carcinoma typically shows greater degree of pleomorphism and mitotic activity. Immunostaining with prostatic markers can help in challenging cases.

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