Cardiac Myxoma : Microscopic Features
Microscopic Features: The myxoid stroma is rich in proteoglycans, elastin, collagen, fibrinogen and fibrin. There are areas of recent and old hemorrhage. Besides tumor cells, the stroma contains dendritic cells, hemosiderin-laden macrophages, and scattered inflammatory cells (lymphocytes, plasma cells, eosinophils and basophils). Typical myxoma appearance may be obscured by secondary changes, including hemorrhage, thrombosis, infarction, cystic degeneration, fibrosis and calcification. Note the close association of tumor cells to vascular spaces in this image.