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Cardiac Angiosarcoma : Immunostains

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Angiosarcoma143_Heart.jpg

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Immunohistochemical Profile of Cardiac Angiosarcoma: Tumor cells are positive for CD31, CD34 (variable), Factor VIII-related antigen, FLI-1 (nuclear), ERG (nuclear), and INI-1 (nuclear). Tumors with lymphatic endothelial differentiation show immunoreactivity for D2-40 and PROX1. Epithelioid angiosarcomas can show focal positivity for cytokeratins and sometimes EMA, but S-100 protein, Melan-A, and HMB-45 are negative. A strong cytokeratin immunoreactivity should suggest another diagnosis. P53 is positive.

This image of cardiac angiosarcoma shows solid areas as well as irregularly-shaped vascular channels infiltrating in between cardiac myocytes (cells with large nuclei).

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