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Solid Pseudopapillary Tumor : NSE

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Pancreas_SolidPseudoPapillaryTumor31_NSE.jpg

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Comments:
The histogenesis of solid pseudopapillary tumor of pancreas is unknown and it expresses a variety of epithelial, mesenchymal, and neuroendocrine markers as follows:

POSITIVE: Keratin (focally positive; 30-70% of cases), synaptophysin (focally positive), CD56 (focally positive), NSE (shown here), CD10, progesterone receptor, CD99 (dot-like positivity), CD117 (but no KIT mutation), cyclin D1, claudin-5, claudin-7, α1 antitrypsin, α1 anti-chymotrypsin, and vimentin.

NEGATIVE: chromogranin, estrogen receptor, trypsin, and chymotrypsin.

The expression patterns for β-catenin, LEF1, and E-cadherin have been discussed in the previous images.

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