Cronkhite-Canada Syndrome
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![GI_Colon_Polyps_Hamartomatous_CronkhiteCanadaSyndr1_resized.jpg](/slides-13/slides/GI_Colon_Polyps_Hamartomatous_CronkhiteCanadaSyndr1_resized.jpg)
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Cronkhite-Canada Syndrome (CCS): This is a rare, sporadic polyposis syndrome with no known genetic defects. The underlying pathogenesis is related to immune dysregulation. Patients are seriously ill and present with malabsorption, diarrhea, protein-losing enteropathy and dermal manifestations (alopecia, onychodystrophy, and hyperpigmentation). Treatment usually consists of corticosteroids or cyclosporine (for steroid-resistant cases). Mortality is as high as 50%. Endoscopy reveals hamartomatous, inflammatory-type polyps throughout the gastrointestinal tract except for esophagus. This endoscopic image shows diffuse involvement of colon. Image courtesy of: @PatholWalker