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Toxoplasma Lymphadenitis

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Toxoplasma Lymphadenitis: Toxoplasma trophozoites are rarely seen in the lymph nodes of immunocompetent patients with routine H&E morphology, immunostains, or by PCR. In immunocompromised patients, such as patients with AIDS, clusters of crescentic shaped trophozoites free or in macrophages may be seen. They are best detected in Giemsa-stained tissue imprints or smears.

Chronic cases of toxoplasmosis may rarely show cysts within involved lymph nodes. In cases with presumptive diagnosis of toxoplasma lymphadenitis on a lymph node biopsy or FNA, serologic studies are helpful in confirming the diagnosis.

This image from a case of toxoplasma lymphadenitis shows monocytoid B-cells in a sheet (left half) and aggregates of epithelioid histiocytes (right half).

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