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NLPHL : Serpiginous Nodular

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HemePath_NLPHL2_PatternB_Serpiginous.jpg

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Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL): This image shows serpiginous nodular architectural pattern (Pattern B) as described by Fan et al (See Reference). It consists of interconnected aggregates of reactive B lymphocytes along with scattered neoplastic lymphocyte-predominant (LP) cells. A few normal reactive follicles sharply demarcated from the tumor tissue are also seen.

Reference:
Fan Z, Natkunam Y, Bair E, et al. Characterization of variant patterns of nodular lymphocyte predominant Hodgkin lymphoma with immunohistologic and clinical correlation. Am J Surg Pathol 2003; 27:1346-56.

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