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Melanoma : Relationship with Nevus

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About 35% of nodular and superficial spreading melanomas arise in a background of melanocytic nevi (congenital, acquired, or dysplastic). Small congenital or acquired nevi rarely develop into melanomas. However, giant congenital nevi have a 3-18% risk of malignant transformation. Lentigo maligna melanoma is not associated with pre-existing benign or dysplastic nevi.

The image shows a melanoma nodule surrounded by benign nevus cells in the dermis. Image copyright: pathorama.ch.

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