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Warthin's Tumor : Immunohistochemistry

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The epithelial component of Warthinís tumor is cytokeratin positive (CK7, 8, 18, and 19) and the lymphoid stroma consists predominantly of IgA-producing polyclonal B-cells with a few T-cells, mast cells, and S-100-positive dendritic cells. This high magnification view of the previous image shows dense lymphocytic infiltrate with prominent germinal center formation. The epithelial component consists of tubular and papillary structures lined by bi-layered epithelium composed of tall columnar luminal cell layer and cuboidal oncocytic cells on outer side.

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