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Castleman's Disease : Mediastinum

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The center of lymphoid follicles in Castlemanís disease is usually depleted of lymphocytes and show follicular dendritic cells. The follicle is surrounded by a broad mantle zone consisting of concentric layers of lymphocytes resulting in an onion-skin appearance. For additional details and images of Castlemanís disease, visit Lymph Node/Spleen section

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