Glioblastoma : Endothelial Hyperplasia
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![Brain_Astrocytoma_GBM1_EndothelialHyperplasia2(1).jpg](/slides-13/slides/Brain_Astrocytoma_GBM1_EndothelialHyperplasia2(1).jpg)
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Besides necrosis with nuclear pseudopalisading, the presence of endothelial proliferation is another histologic hallmark of glioblastomas. The image shows glomeruloid vessels (vessels with multiple lumina) and endothelial multilayering as a result of endothelial hyperplasia. These changes are driven by