Tumoral Calcinosis

Comments:
Tumoral calcinosis has a nodular architecture with fibrous septa coursing between nodules. During the active phase of the lesion, the nodules show a central area of calcification surrounded by macrophages, osteoclast-like multinucleated giant cells, fibroblasts, and chronic inflammatory cells. The cellularity decreases during the inactive phase, leaving behind amorphous or granular calcified material bordered by dense fibrosis.