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Gaucher DIsease

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Spleen_Gaucher'sDisease3A.jpg

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The most common type, Type I (non-neuronopathic form) Gaucher disease results in accumulation of lipids in spleen and skeletal systems. Type II (Acute neuronopathic form) shows CNS involvement with early death. Type III has features intermediate between types I and II. The fibrillary appearance of the cytoplasm of Gaucher cells likened to crumpled tissue paper can be seen here.

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