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Sezary Syndrome : Microscopic Features

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Sezary syndrome (SS) - Microscopic Features: In SS, the findings in diagnostic skin biopsies are similar to the late patch- or plaque stage of mycosis fungoides (MF).

There is a dense band-like lymphocytic infiltrate in the dermis. Epidermotropism is seen in 20%-40% of cases and is less prominent. Small uniform lymphocytes are the predominant cell population. Large atypical cells with cerebriform nuclei (Sezary cells) are in the minority but their presence is helpful in making the diagnosis of SS in the appropriate clinical setting. In a small percentage of cases, the dermal infiltrate is composed entirely of large atypical cells resembling a large cell lymphoma.

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