11,826 Images : Last Update : Nov 19, 2022

Primitive Neuroectodermal Tumor

prev
slide 15 of 17
next
No Image
Kidney_PNET3(1).jpg

Close

Comments:
Some cases of primitive neuroectodermal tumor (PNET) show prominent Homer-Wright rosettes as seen here. Like its bone and soft tissue counterparts, the primary renal PNET also demonstrates (in 90% of cases) EWS-FLI1 gene fusion resulting from translocation t(11;22)(q24;q12). FLI1 belongs to the ETS family of transcription factors. Other genes from this family such as ERG, ETV1, E1AF, FEV, and ZSG may also be involved in fusion with EWS.

prev
slide 15 of 17
next