SMZL - Immunophenotype : BCL2
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![HemePath_Spleen_MZL17_BCL2.jpg](/slides-13/slides/HemePath_Spleen_MZL17_BCL2.jpg)
Comments:
Splenic Marginal Zone Lymphoma (SMZL) - Immunophenotype: The neoplastic cells in a prototypic case have the following profile: Positive Markers: CD20, BCL2, IgD, p27, and MNDA. Negative Markers: CD3, CD23, CD43, CD38, CD5, CD10, BCL6, cyclin D1, and annexin A1. This image shows BCL2 negative germinal centers surrounded by BCL2-positive neoplastic marginal zone component.