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SMZL - Immunophenotype : BCL2

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HemePath_Spleen_MZL17_BCL2.jpg

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Splenic Marginal Zone Lymphoma (SMZL) - Immunophenotype: The neoplastic cells in a prototypic case have the following profile:

Positive Markers: CD20, BCL2, IgD, p27, and MNDA.
Negative Markers: CD3, CD23, CD43, CD38, CD5, CD10, BCL6, cyclin D1, and annexin A1.

This image shows BCL2 negative germinal centers surrounded by BCL2-positive neoplastic marginal zone component.

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