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Cirrhosis in Total Parenteral Nutrition

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Liver_Cirrhosis17_TPN.jpg

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In addition to steatosis and steatohepatitis, long-term total parenteral nutrition (TPN) may result in cholestasis, hepatocellular damage, ductular reaction, fibrosis, and cirrhosis. This case of TPN-induced cirrhosis shows nodules of damaged hepatocytes with steatosis and inspissated bile, which are separated by fibrous bands containing prominent ductular reaction.

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