Gonadoblastoma : Microscopic

Comments:
This image shows a large nest composed of immature large round germ cells with clear cytoplasm (resembling dysgerminoma cells) that are associated with smaller, dark sex cord cells (similar to Sertoli and granulosa cells). There is abundant hyalinized basement membrane material in and around the cell nests. Pure gonadoblastoma is a benign tumor; however, it's clinical course is complicated in 50% of cases by the development of an invasive germ cell tumor (usually Dysgerminoma),