Cardiac Myxoma : Differential Diagnosis
Comments:
Differential Diagnosis: The differential diagnosis of cardiac myxomas includes:
- papillary fibroelastoma - occurs on valves; endothelium-lined avascular papillary fronds; no myxoma cells or inflammatory cells
- primary or metastatic myxoid sarcomas - greater cellularity; pleomorphic spindle cells; increased mitotic activity; necrosis
- metastatic carcinoma - history of carcinoma; no myxoma cells; positive cytokeratin
- mural thrombus - no myxoma cells; abundant granulation tissue; zonation with prominent fibrin and hyalinization
- inflammatory myofibroblastic tumor and hemangioma This image of an atrial myxoma shows stellate, spindle, and oval tumor cells in abundant myxoid matrix. Numerous delicate vascular channels are present. The myxoid matrix contains scattered inflammatory cells.