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Cardiac Myxoma : Differential Diagnosis

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Heart_Tumors_Myxoma50.jpg

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Differential Diagnosis: The differential diagnosis of cardiac myxomas includes:

  • papillary fibroelastoma - occurs on valves; endothelium-lined avascular papillary fronds; no myxoma cells or inflammatory cells
  • primary or metastatic myxoid sarcomas - greater cellularity; pleomorphic spindle cells; increased mitotic activity; necrosis
  • metastatic carcinoma - history of carcinoma; no myxoma cells; positive cytokeratin
  • mural thrombus - no myxoma cells; abundant granulation tissue; zonation with prominent fibrin and hyalinization
  • inflammatory myofibroblastic tumor and hemangioma

  • This image of an atrial myxoma shows stellate, spindle, and oval tumor cells in abundant myxoid matrix. Numerous delicate vascular channels are present. The myxoid matrix contains scattered inflammatory cells.

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