Dedifferentiated Liposarcoma : Gross Pathology

Comments:
Gross Pathology: Dedifferentiated liposarcomas (DLPS) are large multinodular masses of yellow adipose tissue (representing the atypical lipomatous tumor/well-differentiated liposarcoma component) containing solid, firm, pink-tan to grey-white non-lipomatous areas (representing dedifferentiation). The transition between lipomatous and dedifferentiated areas is usually sharply defined but the two areas may be intermixed in some cases. The dedifferentiated areas may show hemorrhage and necrosis.

This specimen photograph shows dedifferentiated liposarcoma (pink-tan nodule at the top) that arose in a well-differentiated (lipoma-like) liposarcoma of the spermatic cord. The testis is dwarfed by the large size of the tumor. Image courtesy of: Felipe D'Almeida, MD, Sao Paulo, Brazil; used with permission