Giant Cell Tumor of Bone
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![Bone_GiantCellTumor5.jpg](/slides-13/slides/Bone_GiantCellTumor5.jpg)
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There is female predominance, especially in the first two decades of life. Peak incidence is in the third decade. Pain and swelling are common presenting symptoms. The image shows a typical case with numerous multinucleated giant cells scattered in a background of uniform mononuclear cells. The giant cells are believed to arise from the fusion of these mononuclear cells.