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Embryonal CA : Solid pattern vs Seminoma

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Solid pattern of embryonal carcinoma may mimic seminoma. Seminoma usually have less cytologic atypia and more distinct cytoplasmic borders. In addition, seminomas are negative for CD30; negative or only focally positive for cytokeratin; and positive for CD117. Embryonal carcinoma usually have reverse immunohistochemical profile (CD30+, cytokeratin +, CD117 neg).

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