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Heterologous Metaplastic Carcinoma

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Breast_CA_Metaplastic39.jpg

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Heterologous metaplastic carcinoma of the breast (same case as the previous two images). Highly atypical tumor cells are seen lining malignant osteoid matrix which is largely unmineralized (except for a small area near the top center and left). The intervening space between the osteoid trabeculae is filled with high-grade spindle cells. This tumor was composed entirely of spindle cells and heterologous elements.

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