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Solid Pseudopapillary Tumor : Treatment & Prognosis

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Treatment & Prognosis: Solid pseudopapillary tumor of pancreas is a slow-growing tumor of low malignant potential. It behaves in a benign manner in most cases. The overall survival is greater than 90%.

The tumor is aggressive in about 20% of cases and associated with recurrences and/or metastasis. There are no reliable morphologic predictors of outcome; however, features associated with malignancy include: large tumor size, necrosis, high mitotic rate, perineural invasion, lymphovascular invasion, invasion of adjacent structures, or metastases. The most common sites of metastasis are the liver (shown here) and peritoneum. About 5% to 10% of patients have metastatic disease at presentation.

The treatment of choice is complete resection. Recurrences occur in 10% to 15% of cases. Local dissemination can occur if the tumor ruptures spontaneously or with trauma. Even with metastases, prolonged survival has been reported.

Image courtesy of: @Patholwalker

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