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Solid Pseudopapillary Tumor : E-cadherin

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Loss of E-cadherin Expression in Solid Pseudopapillary Tumor (SPT) of Pancreas: There is complete loss or abnormal localization (nucleus instead of cell membrane) of E-cadherin expression in SPT. This is not related to mutations in E-cadherin gene, but rather to abnormal expression of partner genes such as β-catenin and p120.

The image shows normal expression of E-cadherin in uninvolved pancreas on the left and complete loss of expression in the tumor on the right.

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