Solid Pseudopapillary Tumor
Microscopic Features of Solid Pseudopapillary Tumor (SPT) of Pancreas: SPT shows varied histologic patterns, including solid, pseudopapillary and hemorrhagic-cystic areas. The solid areas at the periphery of the tumor consist of poorly cohesive sheets of small, uniform polygonal cells admixed with delicate vasculature. The cells have light pink to clear cytoplasm, indistinct nucleoli, and frequent longitudinal nuclear grooves. True gland formation is not seen. Mitotic activity is not increased. Note the resemblance to well-differentiated neuroendocrine tumor.