Lipoma : Cytogenetics
Lipoma Cytogenetics: Majority of lipomas show structural rearrangements of chromosome 12q13-15. Most commonly, this results from translocation t(3;12)(q27-28;q13-15). Less often, the translocations involve 12q13-15 and other chromosomes, including 1p, 2p, 2q, 4q, 5q, 11q, and 12p. One such rearrangement involving 5q is shown here. This image shows metaphase FISH targeting HMGA2 gene in a lipoma. Arrowhead indicates normal chromosome 12. This case had t(5;12)(q33;q14) where the entire HMGA2 locus was translocated to chromosome 5 (arrow). Image Source: Bartuma H, Panagopoulos I, Collin A, Trombetta D, Domanski HA, Mandahl N, Mertens F. Expression levels of HMGA2 in adipocytic tumors correlate with morphologic and cytogenetic subgroups. Mol Cancer. 2009 Jun 9;8:36. doi: 10.1186/1476-4598-8-36. PMID: 19508721; PMCID: PMC2702300; image cropped from original and used under Creative Commons Attribution license.