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Collagenous Colitis : Pathogenesis

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The pathogenesis of collagenous colitis is immune-mediated and it may be related to celiac disease. Exposure to one or more luminal antigens is required. Non-steroidal anti-inflammatory drugs, proton-pump inhibitors, selective serotonin uptake inhibitors (SSRIs), simvastatin, and lisinopril exposure have been associated with collagenous colitis.

This case of collagenous colitis was related to intake of proton pump inhibitor - lansoprazole for gastroesophageal reflux disease. Image courtesy of: @patholwalker

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