Follicular lymphoma is a low-grade B-cell neoplasm composed of follicle center B-cells (centrocytes and centroblasts). The most distinctive morphologic feature is nodular (follicular) pattern. This low-power scan shows a lymph node with follicular lymphoma. The nodal architecture is completely effaced with obliteration of subcapsular and medullary sinuses. The neoplastic follicles are evenly distributed throughout the lymph node. In contrast, the hyperplastic follicles in a reactive lymph node are mainly cortical in distribution.