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Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, LT) : Molecular Genetic Features:
- Gene expression profile of activated B-cell type of DLBCL
- Translocations involving BCL6 (30%), MYC (30%), and IGH (50%)
- BCL2 amplification is seen in 67% of cases
- Loss of CDKN2A by del 9p21.3 or by promoter methylation (67% of cases) portends poor prognosis
- Mutations in NF-κB pathway: MYD88 L265P (60%), CARD11 (10%), CD79B (20%), and TNFAIP3/A20 (40%)
- Recurrent genetic alterations in PDL1/PDL2 in about 40% of cases.