Hepatitis C Virus & MALT Lymphoma
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Hepatitis C Virus (HCV) & MALT Lymphoma: HCV infects both hepatocytes and lymphocytes and has been implicated in the pathogenesis of both hepatocellular carcinoma as well as B-cell non-Hodgkin lymphomas, including extranodal marginal zone lymphomas (EMZL) of MALT type (MALT lymphoma).
Evidence of HCV infection is seen in about one-third of EMZL patients. Cases where lymphoma regressed after antiviral treatment have been documented. EMZL in HCV-infected patients usually occurs in non-gastric sites such as lacrimal gland and salivary glands. The pathogenetic mechanisms in HCV-induced EMZL include direct oncogenic effect of virally-coded proteins and virus-driven immune response.
Image Credit: By Guido4 - Own work; used under Creative Commons Attribution-Share Alike 4.0
Evidence of HCV infection is seen in about one-third of EMZL patients. Cases where lymphoma regressed after antiviral treatment have been documented. EMZL in HCV-infected patients usually occurs in non-gastric sites such as lacrimal gland and salivary glands. The pathogenetic mechanisms in HCV-induced EMZL include direct oncogenic effect of virally-coded proteins and virus-driven immune response.
Image Credit: By Guido4 - Own work; used under Creative Commons Attribution-Share Alike 4.0