Image 58 of 63



Image Description

LCAs related to androgenic steroid use may show cytologic abnormalities consisting of nuclear pleomorphism and atypia, multinucleation, prominent nucleoli, and/or an acinar (pseudoglandular) pattern. Activating beta-catenin gene mutations are present in 10-15% of LCA with cytologic atypia and acini and such cases are more likely to transform to hepatocellular carcinoma. Note the prominent cytoplasmic lipofuscin pigment, which is commonly seen in LCA.

Image 58 of 63