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Juvenile Granulosa Cell Tumor : Immunostains

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Immunohistochemistry of Juvenile Granulosa Cell Tumor: The tumor cells are positive for inhibin, calretinin, WT1, FOXL2, SF-1, SOX9, and CD99. They may also be positive for cytokeratins, S-100 protein, vimentin, smooth muscle actin, and desmin (focal).

SALL4 and glypican-3 are consistently negative and helpful in differentiating from yolk sac tumor.

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