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NK/T-cell Lymphoma

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NK/T-cell lymphoma was previously referred to as angiocentric lymphoma. It shows angiocentric growth with invasion and destruction of vessel walls as illustrated here. The elastic lamina of small arteries is disrupted and there is deposition of fibrinoid material in the walls and lumen. The vascular damage is postulated to be caused by EBV-induced chemokines.

Destruction of blood vessels results in coagulative necrosis and ulceration of the involved tissues. In advanced stages, the lesions may coalesce producing highly disfiguring facial lesions that ultimately prove lethal.

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