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Mesenteric Fibromatosis : Treatment & Prognosis

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Dilated thin-walled vessels are commonly seen in intra-abdominal fibromatosis. Treatment: Asymptomatic lesions may be simply observed. For symptomatic tumors, wide local excision with negative margins is the treatment of choice. When complete surgical extirpation cannot be performed due to risk of damage to vital internal structures, post-operative radiation is used. Other modalities that have been tried with limited success include: imatinib (Gleevec), sorafenib (tyrosine kinase inhibitor), cytotoxic drugs, non-steroidal prostaglandin inhibitors, and anti-estrogen agents. Prognosis: Intra-abdominal fibromatosis has a tendency to recur locally, especially when associated with FAP/Gardner syndrome. Sporadic lesions recur less often and rarely show more than one recurrence.

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