AdenoCA of Colon : Signet Ring Cell

Comments:
Signet ring cell carcinoma of colon showing classic histologic pattern. The intracellular mucin blob pushes the nucleus to one side, flattening it against the cytoplasmic membrane, and creates a signet ring appearance.

Primary signet ring cell carcinoma of colon is rare and makes up about 1% of all colorectal carcinomas. Metastases from sites such as breast, ovary and stomach should be excluded.