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SMZL : Morphology

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HemePath_Spleen_MZL28.jpg

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Splenic Marginal Zone Lymphoma (SMZL) - Morphology: The tumor nodules are composed of a uniform population of lymphoid cells with marginal zone differentiation. They have moderate amounts of pale-staining or clear cytoplasm and slightly irregular nuclei. Scattered large B-cells resembling centroblasts or immunoblasts are often present in both the white and the red pulp (see next image).

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