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Intraductal Papilloma of Breast : Apocrine change

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Breast_Benign_Papilloma_ApocrineChange2.jpg

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This image shows apocrine metaplasia in an intraductal papilloma. The main differential diagnosis is intraductal papillary carcinoma. Features favoring papilloma include: well-developed stroma in papillary folds, two cell types, lack of cytologic atypia, presence of apocrine metaplasia, and lack of cribriform or trabecular patterns.

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