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LCH of Bone : Introduction

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Langerhans Cell Histiocytosis (LCH) of Bone: Bone lesions are the most common clinical presentation in LCH. Bone involvement may be unifocal (eosinophilic granuloma) or multifocal. The lytic bone lesions arise within the medullary cavity, erode the cortex and involve adjacent soft tissue. They may be asymptomatic initially but usually cause pain, tenderness, or pathologic fractures.

About this image: This plain x-ray of skull is from a 5 y/o female who presented with multiple soft tissue swellings on scalp, fever of unknown origin, gait difficulties, and painful limp. There are multiple well-defined punched out osteolytic lesions with scalloped edges in bilateral parietal regions. The diagnosis of LCH was confirmed on a biopsy. Case courtesy of Dr Prashant Mudgal, Radiopaedia.org. From the case rID: 28345

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