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Differential Diagnosis of Undifferentiated Pleomorphic Sarcoma (UPS):
Sarcomatoid Carcinoma: The differential diagnosis of UPS includes sarcomatoid carcinoma, especially when the tumor occurs in the vicinity of epithelial structures or the patient has a history of carcinoma. Some cases of UPS may show focal, patchy expression of keratin; however, strong, diffuse immunoreactivity for pankeratins favors sarcomatoid carcinoma and excludes UPS.
Sarcomatoid Carcinoma: The differential diagnosis of UPS includes sarcomatoid carcinoma, especially when the tumor occurs in the vicinity of epithelial structures or the patient has a history of carcinoma. Some cases of UPS may show focal, patchy expression of keratin; however, strong, diffuse immunoreactivity for pankeratins favors sarcomatoid carcinoma and excludes UPS.