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LCH of Skin : Treatment

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Treatment of Langerhans Cell Histiocytosis (LCH) of Skin: Solitary skin lesions in single system LCH can be treated by limited local excision. Weekly oral methotrexate with or without 6-mercaptopurine has also proven effective. Isolated skin lesions may also respond to light therapy.

This image of LCH of skin shows a uniform population of Langerhans cells (LC) filling up the papillary dermis with some invading the epidermis. The LCs have characteristic folded or grooved nuclei.

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