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Malignant Brenner Tumor : Immunostains

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Ovary_BrennerTumor4_Malignant(1).jpg

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The immunohistochemical profile of malignant Brenner tumors is similar to their benign counterpart. They are positive for CK7, p63, GATA3, uroplakin, thrombomodulin, EMA, CEA and S-100 protein. They are usually negative or only weakly positive for CK20 and p53.

The image shows malignant Brenner tumor resembling a high-grade urothelial carcinoma.

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