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Schwannoma : Ancient Change

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Schwannoma_DegenerativeChange20.jpg

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Degenerative-type cytologic atypia is frequently seen in deep-seated schwannomas arising in the posterior mediastinum or retroperitoneum. It consists of irregular, multilobed hyperchromatic nuclei which frequently contain intranuclear vacuoles. Mitotic activity is not increased. These changes have no prognostic significance. A hyalinized blood vessel is seen at the top left of this image.

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