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Invasive Ductal CA : Nuclear Grade

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The modified Scarff-Bloom Richardson grading system (Nottingham Combined Histologic Grade) is based on the degree of tubule/duct formation, nuclear grade, and mitotic rate.

Nuclear features are assessed in the area with greatest pleomorphism. The tumor nuclei are compared to the nuclei of normal ductal epithelial cells in the adjacent breast tissue. The nuclei are subdivided into three categories: 1) low-grade nuclei (score 1) are small, uniform and comparable in size to those of normal ductal epithelial cells. The chromatin is evenly dispersed and nucleoli are inconspicuous. 2) intermediate grade nuclei (score 2) are 1.5-2x the size of benign ductal epithelial nuclei. They show mild to moderate pleomorphism and small punctate nucleoli. 3) high-grade nuclei (score 3) are more than twice the size of benign ductal epithelial cells. There is marked pleomorphism, vesicular chromatin, and prominent nucleoli.

The tumor shown in this image has highly pleomorphic nuclei (score of 3) with one or more eosinophilic macronucleoli. Incidentally, this case was assigned score of 3 both for tubule formation (solid growth; no tubule formation) as well as mitotic activity (>15 mitoses/10HPF with 40x objective, field area of 0.196 sq.mm). The sum of all three scores was 9 (poorly-differentiated, Grade III, according to Nottingham Combined Histologic Grade).

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